The TISSIUM proprietary technology platform consists of a family of fully synthetic, biomorphic and programmable polymers


Conforms to and integrates
with surrounding tissue
to enable natural healing


Modular polymer design can be
adjusted to match tissue-specific

The versatility of our proprietary family of polymers enables a broad range of possible applications

Inside the body

Our polymers can be applied
directly to tissue and activated
inside the body, acting as
sealants, adhesives,
barriers or plugs

Outside the body

Our polymers can be produced
outside the body, using 3D
printing technology for high
resolution implantable


“Evaluation of a biocompatible sealant for on-demand repair of vascular defects—a chronic study in a large animal model”
Interactive CardioVascular and Thoracic Surgery (2020), ivaa012.

Wussler D, Kiefer S, Naumann S, Hackner D, Nadjiri J, Meckel S, Haberstroh J, Kubicki R, Seifert A, Siepe M, Ewert P, Stiller B, Lang N.

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“Preclinical and Clinical Evaluation of a Novel Synthetic Bioresorbable, On-demand, Light-activated Sealant in Vascular Reconstruction”
Journal of Cardiovascular Surgery (2019).

Pellenc Q, Touma J, Coscas R, Edorh G, Pereira M, Karp J, Castier Y, Desgranges P, Alsac JM.

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“A Light-reflecting Balloon Catheter for a Traumatic Tissue Defect Repair”
Science Translational Medicine (2015), 7(306).

Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Berazaluce AMC, Bueno A, Lang N, Pereira MJN, Feins E, Wasserman S, O’Cearbhaill E, Vasilyev NV, Mooney DJ, Karp JM, Nido PJ, Walsh CJ.

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“A Blood-resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects”
Science Translational Medicine (2014), 6(218).

Lang N*, Pereira MJ*, Lee Y, Friehs I, Vasilyev N, Feins EN, Ablasser K, O’Cearbhaill E, Xu C, Fabozzo A Padera R, Wasserman S, Freudenthal F, Ferreira LS, Karp JM, del Nido PJ. (*) Authors contributed equally.

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“Synthesis and Characterization of Photocurable Elastomers from Poly (Glycerol-Co-Sebacate)”
Biomacromolecules (2007), 8(10).

Nijst CLE, Bruggeman JP, Karp JM, Ferreira L, Zumbuehl A, Bettinger CJ, et al.

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“A Tough Biodegradable Elastomer”
Nature Biotechnology (2002), 20(602).

Wang Y, Ameer G, Sheppard BJ, Langer R.

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“A Highly Tunable Biocompatible and Multifunctional Biodegradable Elastomer”
Advanced Materials (2013), 25(8):1209-1215.

Pereira MJ, Oyuang B, Sarkar D, Lang N, Sundback C, Friehs N, Mureli S, Pomerantseva I, McFaden J, Masiakos P, del Nido P, Langer R Ferreira LS, Karp JM.

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“Combined Surface Micropatterning and Reactive Chemistry for Maximizing Tissue Adhesion with Minimal Inflammation”
Advanced Healthcare Materials (2014), 3(4):565-571.

Pereira MJ, Sundback C, Lang N, Cho WK, Pomerantseva I, Ouyang B, Tao S, Mwizerwa O, Vemula PK, Mochel MC, Carter DJ Borenstein JT, Langer R, Ferreira LS, Karp JM, Masiakos P.

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