Biomorphic Programmable Polymers

 

Our proprietary biomorphic programmable polymers enable tissue reconstruction and can be adapted for use in multiple clinical areas

Biomorphic

Conforms to and integrates with surrounding tissue to enable tissue reconstruction

Programmable

Polymer building blocks can be adjusted to match tissue-specific requirements

Our polymer technology is based on the combination of safe, naturally occurring compounds, such as glycerol and sebacic acid.

A viscous pre-polymer can be precisely applied to tissues, with minimal displacement by body fluids, during surgical procedures.

The high viscosity of the pre-polymer allows it to be precisely applied with minimal displacement by body fluids.

The viscous pre-polymer is activated on-demand, within seconds, using a visible blue light

The resulting bond is both adhesive and elastic, allowing the polymer to comply with the underlying tissue while remaining strongly adhered.

The pre-polymer can also be used as a resin to build high-resolution 3D-printed devices.

The pre-polymer can also be loaded with drugs and deployed potentially anywhere in the body, creating a depot that elutes drugs locally for extended periods.

Versatile applications

Tissue Sealants

We develop tissue sealants for use in cardiovascular procedures.

Tissue Adhesives

We develop tissue adhesives for use in peripheral nerve and gastrointestinal procedures.

3D-Printed Implants

We design surgical scaffolds using 3D printing technology for peripheral nerve repair.

Localized Drug Delivery

We formulate drug-eluting adhesives for the treatment of ENT diseases.

Publications

“Evaluation of a biocompatible sealant for on-demand repair of vascular defects—a chronic study in a large animal model”

Interactive CardioVascular and Thoracic Surgery (2020), ivaa012.


Wussler D, Kiefer S, Naumann S, Hackner D, Nadjiri J, Meckel S, Haberstroh J, Kubicki R, Seifert A, Siepe M, Ewert P, Stiller B, Lang N.

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“Preclinical and Clinical Evaluation of a Novel Synthetic Bioresorbable, On-demand, Light-activated Sealant in Vascular Reconstruction”

Journal of Cardiovascular Surgery (2019).


Pellenc Q, Touma J, Coscas R, Edorh G, Pereira M, Karp J, Castier Y, Desgranges P, Alsac JM.

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“A Light-reflecting Balloon Catheter for a Traumatic Tissue Defect Repair”

Science Translational Medicine (2015), 7(306).


Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Berazaluce AMC, Bueno A, Lang N, Pereira MJN, Feins E, Wasserman S, O’Cearbhaill E, Vasilyev NV, Mooney DJ, Karp JM, Nido PJ, Walsh CJ.

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“A Blood-resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects”

Science Translational Medicine (2014), 6(218).


Lang N*, Pereira MJ*, Lee Y, Friehs I, Vasilyev N, Feins EN, Ablasser K, O’Cearbhaill E, Xu C, Fabozzo A Padera R, Wasserman S, Freudenthal F, Ferreira LS, Karp JM, del Nido PJ. (*) Authors contributed equally.

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“Synthesis and Characterization of Photocurable Elastomers from Poly (Glycerol-Co-Sebacate)”

Biomacromolecules (2007), 8(10).


Nijst CLE, Bruggeman JP, Karp JM, Ferreira L, Zumbuehl A, Bettinger CJ, et al.

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“A Tough Biodegradable Elastomer”

Nature Biotechnology (2002), 20(602).


Wang Y, Ameer G, Sheppard BJ, Langer R.

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“A Highly Tunable Biocompatible and Multifunctional Biodegradable Elastomer”

Advanced Materials (2013), 25(8):1209-1215.


Pereira MJ, Oyuang B, Sarkar D, Lang N, Sundback C, Friehs N, Mureli S, Pomerantseva I, McFaden J, Masiakos P, del Nido P, Langer R Ferreira LS, Karp JM.

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“Combined Surface Micropatterning and Reactive Chemistry for Maximizing Tissue Adhesion with Minimal Inflammation”

Advanced Healthcare Materials (2014), 3(4):565-571.


Pereira MJ, Sundback C, Lang N, Cho WK, Pomerantseva I, Ouyang B, Tao S, Mwizerwa O, Vemula PK, Mochel MC, Carter DJ Borenstein JT, Langer R, Ferreira LS, Karp JM, Masiakos P.

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