Biomorphic Programmable Polymers
Our proprietary biomorphic programmable polymers enable tissue reconstruction and can be adapted for use in multiple clinical areas
Biomorphic
Conforms to and integrates with surrounding tissue to enable tissue reconstruction
Programmable
Polymer building blocks can be adjusted to match tissue-specific requirements
Our polymer technology is based on the combination of safe, naturally occurring compounds, such as glycerol and sebacic acid.
A viscous pre-polymer can be precisely applied to tissues, with minimal displacement by body fluids, during surgical procedures.
The viscous pre-polymer is activated on-demand, within seconds, using a visible blue light
The resulting elastomeric bond ensures fixation, allowing the polymer to comply with the underlying tissue while remaining strongly fixed.
The pre-polymer can also be used as a resin to build high-resolution 3D-printed devices.
The pre-polymer can also be loaded with drugs and deployed potentially anywhere in the body, creating a depot that elutes drugs locally for extended periods.
TISSIUM developed State-of-the-art manufacturing capabilities for making aseptic prefilled syringes & 3D printed implants.
Versatile applications
Tissue Sealants
We develop tissue sealants for use in cardiovascular procedures.
Tissue Fixation
We develop solutions for use in peripheral nerve and gastrointestinal procedures.
3D-Printed Implants
We design surgical scaffolds using 3D printing technology for tissue reconstruction.
Localized Drug Delivery
We Formulate drug-eluting solutions for Tissue Repair.
Publications
“Biomechanical Evaluation of an Atraumatic Polymer-assisted Peripheral Nerve Repair System Compared with Conventional Neurorrhaphy Techniques”
Plastic & Reconstructive Surgery-Global Open 12(9):p e6151, September 2024.
Wlodarczyk, Alexie I. MS, MEng*; Collin, Estelle C. MS, PhD*; Pereira, Maria J.N. PhD*; Bindra, Randy MBBS, FRACS, FRCS, MSOrth, MChOrth, FAOrthA†; Power, Dominic M. MA, MB, BChir (Cantab), FRCS (Trauma and Orth)‡
“Evaluation of a biocompatible sealant for on-demand repair of vascular defects—a chronic study in a large animal model”
Interactive CardioVascular and Thoracic Surgery (2020), ivaa012.
Wussler D, Kiefer S, Naumann S, Hackner D, Nadjiri J, Meckel S, Haberstroh J, Kubicki R, Seifert A, Siepe M, Ewert P, Stiller B, Lang N.
“Preclinical and Clinical Evaluation of a Novel Synthetic Bioresorbable, On-demand, Light-activated Sealant in Vascular Reconstruction”
Journal of Cardiovascular Surgery (2019).
Pellenc Q, Touma J, Coscas R, Edorh G, Pereira M, Karp J, Castier Y, Desgranges P, Alsac JM.
“A Light-reflecting Balloon Catheter for a Traumatic Tissue Defect Repair”
Science Translational Medicine (2015), 7(306).
Roche ET, Fabozzo A, Lee Y, Polygerinos P, Friehs I, Schuster L, Whyte W, Berazaluce AMC, Bueno A, Lang N, Pereira MJN, Feins E, Wasserman S, O’Cearbhaill E, Vasilyev NV, Mooney DJ, Karp JM, Nido PJ, Walsh CJ.
“A Blood-resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects”
Science Translational Medicine (2014), 6(218).
Lang N*, Pereira MJ*, Lee Y, Friehs I, Vasilyev N, Feins EN, Ablasser K, O’Cearbhaill E, Xu C, Fabozzo A Padera R, Wasserman S, Freudenthal F, Ferreira LS, Karp JM, del Nido PJ. (*) Authors contributed equally.
“Synthesis and Characterization of Photocurable Elastomers from Poly (Glycerol-Co-Sebacate)”
Biomacromolecules (2007), 8(10).
Nijst CLE, Bruggeman JP, Karp JM, Ferreira L, Zumbuehl A, Bettinger CJ, et al.
“A Tough Biodegradable Elastomer”
Nature Biotechnology (2002), 20(602).
Wang Y, Ameer G, Sheppard BJ, Langer R.
“A Highly Tunable Biocompatible and Multifunctional Biodegradable Elastomer”
Advanced Materials (2013), 25(8):1209-1215.
Pereira MJ, Oyuang B, Sarkar D, Lang N, Sundback C, Friehs N, Mureli S, Pomerantseva I, McFaden J, Masiakos P, del Nido P, Langer R Ferreira LS, Karp JM.
“Combined Surface Micropatterning and Reactive Chemistry for Maximizing Tissue Adhesion with Minimal Inflammation”
Advanced Healthcare Materials (2014), 3(4):565-571.
Pereira MJ, Sundback C, Lang N, Cho WK, Pomerantseva I, Ouyang B, Tao S, Mwizerwa O, Vemula PK, Mochel MC, Carter DJ Borenstein JT, Langer R, Ferreira LS, Karp JM, Masiakos P.
“In vitro controlled release of extracellular vesicles for cardiac repair from poly(glycerol sebacate) acrylate-based polymers”
Acta Biomater. 2020 Oct 1;115:92-103. doi: 10.1016/j.actbio.2020.08.015. Epub 2020 Aug 16. PMID: 32814141.
Thomas Hamada, Julie L N Dubois, Valérie Bellamy, Laetitia Pidial, Albert Hagège, Maria N Pereira, Philippe Menasché
